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1

Phorboxazole synthetic studies: design, synthesis and biological evaluation of phorboxazole A and hemi-phorboxazole A related analogues

Amos B. Smith III, Anne-Marie L. Hogan, Zhuqing Liu, Thomas M. Razler, Regina M. Meis, Brandon I. Morinaka, Tadeusz F. Molinski

Journal:

Year:

2011

Language:

english

File:

PDF, 1.12 MB

english, 2011

2

A Robust Three-Step Telescoped Synthesis of Electron- Deficient Amide Substituted Arylboronic Acids

Zhu, Jason, Razler, Thomas M., Xu, Zhongmin, Conlon, David A., Sortore, Eric W., Fritz, Alan W., Demerzhan, Roman, Sweeney, Jason T.

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 967 KB

english, 2011

3

Synthesis of Pyrimido[4,5-b]indoles and Benzo[4,5]furo[2,3-d]pyrimidines via Palladium-Catalyzed Intramolecular Arylation.

Yue-Mei Zhang, Thomas Razler, Paul F. Jackson

Journal:

Year:

2003

File:

PDF, 203 KB

2003

4

ChemInform Abstract: A Preparatively Convenient Ligand-Free Catalytic PEG 2000 Suzuki—Miyaura Coupling.

Thomas M. Razler, Yi Hsiao, Feng Qian, Ruiling Fu, Rana Kashif Khan, Wendel Doubleday

Journal:

Year:

2009

File:

PDF, 27 KB

2009

5

Synthesis of pyrimido[4,5-b]indoles and benzo[4,5]furo[2,3-d]pyrimidines via palladium-catalyzed intramolecular arylation

Yue-Mei Zhang, Thomas Razler, Paul F. Jackson

Journal:

Tetrahedron Letters

Year:

2002

Language:

english

File:

PDF, 305 KB

english, 2002

6

Degradation kinetics and mechanism of an oxadiazole derivative, design of a stable drug product for BMS-708163, a γ-secretase inhibitor drug candidate

Ruiling F. Hartley, Yande Huang, Michael Cassidy, Thomas M. Razler, Feng Qian, Munir A. Hussain

Journal:

Journal of Pharmaceutical Sciences

Year:

2012

Language:

english

File:

PDF, 548 KB

english, 2012

7

A Preparatively Convenient Ligand-Free Catalytic PEG 2000 Suzuki−Miyaura Coupling

Razler, Thomas M., Hsiao, Yi, Qian, Feng, Fu, Ruiling, Khan, Rana Kashif, Doubleday, Wendel

Journal:

Journal of Organic Chemistry

Year:

2009

Language:

english

File:

PDF, 275 KB

english, 2009

8

(+)-Phorboxazole A Synthetic Studies. Identification of a Series of Highly Cytotoxic C(45−46) Analogues

Smith, Amos B., Razler, Thomas M., Pettit, George R., Chapuis, Jean-Charles

Journal:

Organic Letters

Year:

2005

Language:

english

File:

PDF, 128 KB

english, 2005

9

(+)-Phorboxazole A Synthetic Studies. A Highly Convergent, Second Generation Total Synthesis of (+)-Phorboxazole A

Smith, Amos B., Razler, Thomas M., Ciavarri, Jeffrey P., Hirose, Tomoyasu, Ishikawa, Tomoyasu

Journal:

Organic Letters

Year:

2005

Language:

english

File:

PDF, 112 KB

english, 2005

10

Synthesis and Biological Evaluation of Phorboxazole Congeners Leading to the Discovery and Preparative-Scale Synthesis of (+)-Chlorophorboxazole A Possessing Picomolar Human Solid Tumor Cell Growth Inhibitory Activity

Smith, Amos B., Razler, Thomas M., Meis, Regina M., Pettit, George R.

Journal:

Journal of Organic Chemistry

Year:

2008

Language:

english

File:

PDF, 270 KB

english, 2008

11

Design and Synthesis of a Potent Phorboxazole C(11−15) Acetal Analogue

Smith, Amos B., Razler, Thomas M., Meis, Regina M., Pettit, George R.

Journal:

Organic Letters

Year:

2006

Language:

english

File:

PDF, 84 KB

english, 2006

12

Evolution of the Petasis−Ferrier Union/Rearrangement Tactic: Construction of Architecturally Complex Natural Products Possessing the Ubiquitous cis -2,6-Substituted Tetrahydropyran Structural Element

Smith, Amos B., Fox, Richard J., Razler, Thomas M.

Journal:

Accounts of Chemical Research

Year:

2008

Language:

english

File:

PDF, 468 KB

english, 2008

13

A Second-Generation Total Synthesis of (+)-Phorboxazole A

Smith, Amos B., Razler, Thomas M., Ciavarri, Jeffrey P., Hirose, Tomoyasu, Ishikawa, Tomoyasu, Meis, Regina M.

Journal:

Journal of Organic Chemistry

Year:

2008

Language:

english

File:

PDF, 265 KB

english, 2008

14

Mono-Oxidation of Bidentate Bis-Phosphines in Catalyst Activation: Kinetic and Mechanistic Studies of a Pd/Xantphos-Catalyzed C-H Functionalization

Ji, Yining, Plata, Erik, Regens, Christopher S., Hay, Michael, Schmidt, Michael, Razler, Thomas M., Qiu, Yuping, Geng, Peng, Hsiao, Yi, Rosner, Thorsten, Eastgate, Martin D., Blackmond, Donna G

Journal:

Journal of the American Chemical Society

Year:

2015

Language:

english

File:

PDF, 2.31 MB

english, 2015

15

Development of a Practical Synthesis of Functionalized Azaxanthene-Derived Nonsteroidal Glucocorticoid Receptor Modulators

Conlon, David A., Natalie, Kenneth J., Cuniere, Nicolas, Razler, Thomas M., Zhu, Jason, de Mas, Nuria, Tymonko, Steven, Fraunhoffer, Kenneth J., Sortore, Eric, Rosso, Victor W., Xu, Zhongmin, Adams, M

Journal:

Organic Process Research & Development

Year:

2016

Language:

english

File:

PDF, 921 KB

english, 2016

16

Nickel-Catalyzed Synthesis of Quinazolinediones

Beutner, Gregory L., Hsiao, Yi, Razler, Thomas, Simmons, Eric M., Wertjes, William

Journal:

Organic Letters

Year:

2017

Language:

english

File:

PDF, 1003 KB

english, 2017

17

From Drying Kinetics, Solvate Structure, Particle Morphology and Modeling to Optimal Drying Protocol

Hsieh, Daniel S, Gao, Qi, Huang, Ming Hsing, DiMemmo, Lynn M., Lindrud, Mark, Razler, Thomas M.

Journal:

Organic Process Research & Development

Year:

2017

Language:

english

File:

PDF, 3.38 MB

english, 2017

18

Development of a Kilogram-Scale Process for the Enantioselective Synthesis of 3-Isopropenyl-cyclohexan-1-one via Rh/DTBM-SEGPHOS-Catalyzed Asymmetric Hayashi Addition Enabled By 1,3-Diol Additives

Simmons, Eric M., Mudryk, Boguslaw, Lee, Andrew G., Qiu, Yuping, Razler, Thomas M., Hsiao, Yi

Journal:

Organic Process Research & Development

Year:

2017

Language:

english

File:

PDF, 1.27 MB

english, 2017

19

Adventures in Atropisomerism: Development of a Robust, Diastereoselective, Lithium-Catalyzed Atropisomer-Forming API Step

Wisniewski, Steven R., Carrasquillo-Flores, Ronald, Lora gonzalez, Federico, Ramirez, Antonio, Casey, Matthew, Soumeillant, Maxime C., Razler, Thomas M., Mack, Brendan

Journal:

Organic Process Research & Development

Year:

2018

Language:

english

File:

PDF, 817 KB

english, 2018

20

Development and implementation of a quality control strategy for an atropisomer impurity grounded in a risk-based probabilistic design space

Lora Gonzalez, Federico, Tabora, Jose, Huang, Eric C., Wisniewski, Steven R., Carrasquillo-Flores, Ronald, Razler, Thomas M., Mack, Brendan

Journal:

Organic Process Research & Development

Year:

2019

Language:

english

File:

PDF, 1.90 MB

english, 2019